Vaccines have played a crucial role in combating the Covid-19 pandemic, helping to prevent severe illness and death. However, in an extremely rare case, a Covid booster shot reactivated tuberculosis (TB) in a 47-year-old man who had been living with a dormant infection. This unprecedented immune response raises questions about how vaccines interact with underlying health conditions, particularly in immunocompromised individuals.
This article explores how the Covid booster reawakened TB, the science behind immune system reactions, and what this case means for future vaccination strategies.
The Unusual Case: Covid Booster Triggers Tuberculosis
A 47-year-old man in India had been living with latent tuberculosis—a silent infection that remains in the body without causing symptoms. Before his Covid vaccinations, he showed no signs of active TB and had tested negative for the disease during routine screenings.
However, things took a shocking turn after his third Covid booster shot. Within just five days, he began experiencing severe symptoms, including:
✔ High fever
✔ Excessive night sweats
✔ Extreme fatigue
✔ Painful swelling in his lymph nodes
Doctors initially suspected an autoimmune reaction, but further tests revealed that his dormant TB infection had become active, a rare occurrence known as tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS).
Understanding TB-IRIS: A Hyperactive Immune Response
What is TB-IRIS?
TB-IRIS is a condition where a weakened immune system suddenly regains strength and aggressively attacks a dormant TB infection, causing excessive inflammation. It is most commonly seen in HIV patients when they start antiretroviral therapy, but this case suggests that Covid vaccines could also trigger similar immune responses in some individuals.
Video : Covid booster vaccine reawakens world’s deadliest virus inside man’s body
How Did the Covid Vaccine Play a Role?
Covid mRNA vaccines are designed to stimulate the immune system by mimicking viral proteins. This triggers the body to produce a strong defense against potential infections. However, in rare cases, the immune system may become too aggressive and start attacking latent infections like TB, which had previously been controlled by the body.
The man’s immune system, reawakened by the Covid booster, mistakenly identified his dormant TB bacteria as a new threat, leading to a full-blown inflammatory response.
A Misdiagnosed Condition: The Road to Discovery
Before this incident, the patient had been diagnosed with rheumatoid arthritis (RA)—an autoimmune condition that causes chronic joint pain. To treat RA, he was prescribed immunosuppressive drugs, which weakened his immune system and may have allowed TB bacteria to remain inactive.
But when he received his Covid booster, the sudden immune reactivation overwhelmed his body, making the TB infection spread rapidly and causing severe inflammation.
Symptoms That Led to a TB Diagnosis
The man’s initial symptoms were mistakenly linked to arthritis and Covid vaccine side effects. However, as his condition worsened, doctors conducted further tests, revealing:
✔ Severe swelling in lymph nodes (especially in the neck)
✔ CT scan abnormalities indicating TB inflammation
✔ Biopsy confirming tuberculosis
He was immediately placed on a four-drug TB treatment plan, which led to significant improvement within five days.
A Second Shock: TB Symptoms Return After Third Booster
Just two weeks later, the man received his third Covid booster shot—and his TB symptoms returned even more aggressively.
🔴 Severe chills and fever
🔴 Uncontrollable night sweats
🔴 Extreme weakness
This time, doctors quickly identified TB-IRIS as the cause. His immune system had once again been overstimulated, leading to a dangerous inflammatory reaction.
How Was He Treated?
Doctors acted fast to control his immune response while keeping his TB treatment on track. His treatment plan included:
✔ High-dose intravenous (IV) steroids for five days to calm the immune system
✔ A slow transition to oral steroids for three months
✔ Continued TB medication for over a year
By his 18-month follow-up, his TB symptoms had fully disappeared, and he was finally able to resume arthritis treatment.
Video : A man deliberately got 217 Covid shots. Here’s what happened
What Does This Mean for Future Vaccinations?
This case does not mean that Covid vaccines cause tuberculosis. Instead, it highlights how vaccines can trigger unexpected immune responses in individuals with hidden or latent infections.
Key Takeaways for Patients with Immune Conditions:
🔹 Screening before vaccination: Patients with a history of autoimmune disorders, chronic infections, or immunosuppressive treatments should consult their doctors before getting a booster shot.
🔹 Monitoring for post-vaccine symptoms: If unusual symptoms occur after a vaccine, immediate medical attention is crucial to prevent severe complications.
🔹 Individualized vaccination approaches: Not everyone reacts to vaccines the same way. High-risk patients may require adjusted booster schedules or additional monitoring.
Other Inflammatory Reactions Linked to mRNA Vaccines
While mRNA vaccines are highly effective, there have been reports of immune-related side effects, including:
⚠️ Myocarditis (heart muscle inflammation)
⚠️ Pericarditis (inflammation around the heart lining)
⚠️ Autoimmune disease flare-ups in some individuals
This does not mean vaccines are dangerous, but rather that certain individuals with pre-existing immune conditions may need extra precautions when receiving booster shots.
Final Thoughts: A Rare but Important Medical Case
This case of TB reactivation after a Covid booster is an extremely rare occurrence, but it serves as a reminder of how complex the human immune system is.
While vaccines remain a crucial tool in fighting infectious diseases, this case highlights the importance of personalized medicine—tailoring vaccination plans to each individual’s unique health condition.
If you or someone you know has a history of autoimmune disease, chronic infections, or immune-related conditions, it’s always best to consult a doctor before receiving a booster shot. Awareness and proactive healthcare can prevent rare complications while still ensuring protection against deadly viruses.
What are your thoughts on this case? Have you or someone you know experienced an unusual immune reaction after a vaccine? Let us know in the comments!
I Kept Returning to the Same Café and Tipping $50 Each Time for a Reason the Waitress Couldn’t Imagine
For years, I drove two hours every Friday to visit a small suburban café, leaving unusually large tips for one particular waitress. What she didn’t know was that I carried a life-changing secret in my purse. I just wished I could find the courage to share it.
The Friday evening traffic crawled along the interstate as I made my way out of downtown. My colleagues at the law firm thought I was crazy to drive two hours just for dinner at some suburban café, but they didn’t understand. I didn’t go for the coffee or the sandwiches. I went to see her.
Woman in her 30s driving on a rainy road | Source: Midjourney
The café sat on a quiet corner, its red-brick exterior softened by white trim. It also had a white awning and window boxes full of purple petunias. The bell above the door chimed as I pushed it open, and the familiar scent of coffee and fresh-baked pie made me feel at home.
She looked up when I walked in—the waitress with kind eyes and silver-streaked hair. Her name tag read “Martha,” but I’d known that long before I ever set foot in this place.
Woman in her 50s wearing a waitress uniform in a café with a kind smile | Source: Midjourney
Every time I saw her, I thought about what I held in my purse. And yet, I never knew if I would be brave enough to show it to her that day.
“Welcome back, hon,” she said, already reaching for the coffee pot. “Your usual spot?”
I nodded, sliding into my regular booth by the window. The vinyl seats squeaked beneath me, and the tabletop showed years of wear under its polished surface.
Woman in her 30s sitting in the booth of a café looking expectant | Source: Midjourney
Martha set down a mug of black coffee and pulled out her order pad, though we both knew what I wanted. “Apple pie and an espresso?” she asked, her pen hovering over the paper.
“Yes, please.”
Her smile carried a warmth that made my chest ache. Did she ever wonder about me? Did she even remember me?
The truth sat heavy in my purse, wrapped in a manila envelope that was starting to show wear from months of being carried back and forth. Inside were the documents from the adoption agency, the ones that had turned my world upside down just a few months ago.
Woman in her 30s sitting in the booth of a café holding a purse and looking worried | Source: Midjourney
I still remember the day I finally confronted my adoptive parents about my past. Mother had been arranging flowers in their living room, each stem placed with surgical precision.
“We gave you everything,” she’d said, not bothering to look up from her roses. “The best schools, the finest opportunities. Why isn’t that enough?”
“Because it’s not about things, Mother. It’s about knowing who I am.”
Woman in her 30s looking upset while her mother stands in the background with her arms crossed in an expensive foyer | Source: Midjourney
“You’re one of us,” Father had interjected from behind his iPad. “That’s who you are. But if you insist on pursuing this… project, contact the agency yourself. We won’t stand in your way.”
His tone made it clear they wouldn’t help, either. After 38 years, I should have expected nothing less. My adoptive family had always treated emotions like unwelcome houseguests.
Luckily, I didn’t have trouble contacting the agency, and their response arrived faster than I’d expected. As I read through the documents in my condo, pieces of my past clicked into place.
Woman in her 30s sitting on a couch in the living room of a condo reading documents and looking surprised | Source: Midjourney
My birth mother had died bringing me into the world. My birth father had been too overwhelmed by grief and responsibility, so he had walked away. And then there was Martha—my foster mother for two precious years.
She was the one spot of warmth I remembered from my entire childhood. Unfortunately, her husband’s cancer diagnosis forced them to make an impossible choice.
Martha returned with my pie, setting it down with the same care she always showed. “Anything else you need, sweetie?”
Woman in her 50s wearing a waitress uniform in a café smiling and holding a notepad | Source: Midjourney
I opened my mouth, willing the words to come. The envelope pressed against my ribs through my purse. Just tell her, I thought. Just reach in, pull it out, and tell her.
Instead, I shook my head and smiled weakly. “No, thank you.”
She lingered a moment longer than usual, and I wondered if she sensed something. Did she see how my hands shook slightly as I picked up my fork?
Woman in her 50s wearing a waitress uniform in a café frowning and lingering by a booth | Source: Midjourney
If she did, she said nothing and went to another table while I started eating my pie. When I finished, I left my usual $50 tip on the table. It was excessive for coffee and pie, but how do you put a price on lost time?
Maybe I also left so much because I felt guilty for not being brave enough to tell her who I was today, either. Why was it that I could face the most intimidating lawyers in court without sweating, but this part of my past had me acting like a little girl?
I was disappointed in myself, so I stood. Next Friday, I’ll do it for sure, I promised.
Woman in her 30s with a brown leather purse looking disappointed standing by a booth in a café | Source: Midjourney
Rain had started to fall heavily outside. I fumbled with my umbrella, almost dropping my keys on my way to my car.
“Hey, you!”
I froze, my keys hovering near the car door lock.
“Why are you doing this?!”
I turned to see Martha standing a few feet away, still in her work apron. She held up the money I’d given her.
Woman in her 50s wearing a waitress uniform holding money in one hand and looking concerned outside a red-bricked café | Source: Midjourney
“Every week, you come in,” she continued, taking a step closer. “You sit quietly, leave these large tips, and disappear. Why?”
My heart pounded so hard I thought it might break through my ribs. This was the moment I’d both longed for and dreaded. Yet, I knew I had to take this chance.
“I… I have something for you.” My voice sounded strange to my own ears as I reached into my purse with trembling fingers.
The envelope was slightly bent at the corners now.
Woman’s hand handing over an envelope in a rainy parking lot | Source: Midjourney
“Could you please read this?” I asked, holding it out. “When you have a moment?”
Martha took it slowly, confusion drawing her brows together. “What is this about?”
“It’s about me,” I whispered. “About us.”
She opened it right there, heedless of the rain. I watched her face as she read and saw the moment recognition dawned. Her hand flew to her mouth, and she stumbled backward.
Woman in her 50s wearing a waitress uniform holding a manila envelope and looking shocked while standing outside a red-bricked café in the rain | Source: Midjourney
“Oh my God,” she breathed. “Sarah? My little Sarah?”
I nodded, tears spilling down my cheeks. “Yeah…”
We just looked at one another for an infinite moment.
“Oh, sweetie. I see from these documents that you must have figured out what happened. But you have to understand that John… my husband, your foster father… he got so sick,” she said finally. “The bills kept piling up. This couple came along. They were so wealthy. They could give you everything we couldn’t.”
“I understand perfectly,” I said softly, and I did. I knew they did what they thought was best for me. She didn’t need to explain herself. “What happened to John?”
Woman in her 30s talking to a woman in her 50s in a rainy parking lot outside a red-bricked café | Source: Midjourney
“Cancer took him three years after you were adopted…” She swallowed hard. “He loved you so much, Sarah. We both did. Every day since we let you go, I’ve wondered if we made the right choice.”
“I have… fragments of memories,” I admitted. “Someone reading ‘Goodnight Moon.’ The smell of cookies baking. A man’s laugh. Me calling you Momma. I always told myself I was making it up.”
Martha nodded through her tears. “You wouldn’t go to sleep without that book,” she smiled. “And John would spend hours in the kitchen with you, letting you ‘help’ make cookies. You were only two, but you were so determined to do everything yourself. As soon as you could speak, you called us Momma and Papa.”
Little girl standing on a stool helping make cookies | Source: Midjourney
The rain came down harder, soaking us even more. Eager to hear more, we ran and waited below the awning in front of the café.
Martha told me about my early days, about the love that had filled their modest home. I shared stories about growing up with my adoptive parents. I was financially secure, yes, but emotionally… that was a different story.
“I contacted the agency a few months ago and started coming here,” I confessed after telling her about my current life and career. “Every time I tried to tell you, I lost my nerve.”
Woman in her 30s talking to a woman in her 50s beneath the awning of a red-bricked café | Source: Midjourney
“So you left those tips instead?” Martha’s eyes crinkled with understanding.
“It was the only way I knew how to reach out.”
Suddenly, we heard a sharp tap on the window. It was Martha’s manager, beckoning her inside. “I have to go back to work,” she told me, her eyebrows pulling down apologetically. “Will you come next Friday?”
“Actually… could we maybe do breakfast instead? Tomorrow?”
“Oh, honey,” Martha said, wrapping me into the best hug I’d ever gotten. “I would love nothing more.” When we separated, she pulled out her phone. “Here, write down my number.”
Woman in her 30s hugging a woman in her 50s, smiling and emotional, beneath the awning of a red-bricked café | Source: Midjourney
“Thank you,” I said, after putting my phone back in my pocket. “Bye, Momma.”
Martha’s hand flew to her mouth at my words. “Bye, sweetie. See you soon.”
The rain stopped as I drove back to the city, and stars peeked through breaks in the clouds.
I couldn’t wait to see her again.
Don’t get me wrong. I knew my life, despite its beginning, had been privileged; my adoptive parents had provided everything they could, paving the way for all my success. For that, I will always be grateful.
But sometimes, pure warmth and love are all a person needs. I had experienced that with Momma and Papa, and now, at least, I had her back in my life.
Woman in her 30s driving on a dark rainy road smiling brightly | Source: Midjourney
This work is inspired by real events and people, but it has been fictionalized for creative purposes. Names, characters, and details have been changed to protect privacy and enhance the narrative. Any resemblance to actual persons, living or dead, or actual events is purely coincidental and not intended by the author.
The author and publisher make no claims to the accuracy of events or the portrayal of characters and are not liable for any misinterpretation. This story is provided “as is,” and any opinions expressed are those of the characters and do not reflect the views of the author or publisher.
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