The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
‘American Pickers’ Frank Fritz put under guardianship – things started going downhill after bad engagement – Latest news!
We occasionally follow paths in life that we never would have imagined. Although Frank Fritz was a well-liked character on television, he was going through a lot in his personal life.
This is his tragic tale…
Longtime partner of Frank Fritz was Diann Bankson. His tumultuous split from her resulted in his drinking, unemployment, and even a medical emergency. Although the two are now permanently apart, their time spent together left a lasting impression on them both.]
At the age of 25, Frank Fritz, the host of “American Pickers,” first laid eyes on Diann Bankson. The pair intermittently dated before being engaged in 2017. They moved in together after purchasing an Iowa farmhouse a year later in 2018.
Their relationship, however, soured in November of that year when Bankson claimed to have “walked in” on Fritz and “caught him in bed with another woman.”
Fritz disclosed in an interview that Bankson had cheated on him and that he was even reminded of her “betrayal” by a tattoo. However, he declared his desire to wed her.
“I had planned to get married, had purchased a house and a very expensive ring, and was shocked to learn that my fiancée had been seeing someone else for the previous 2.5 years,” Fritz remarked.
Fritz stated, “She’s the cheater, which is why I got a tattoo saying ‘Once a cheater, always a cheater.’” He said that the tattoo was meant to act as a reminder to never do “the same mistake again.” And that Bankson had “cost” him a lot of money, he said.
He started drinking to heal his broken heart. That’s how he handled his heartbreak, he claimed. He lost a lot of weight as a result of this as well. “I gave it a good shot,” remarked Fritz. I made an attempt to drown her.
He overcame his drinking issue, but because the last relationship with Bankson had “stung hard enough,” he made the decision to put off dating for a while.
Following the split, he had losses in his career as well. The Sun claims that after March 2020, he stopped hosting History Channel’s “American Pickers.”
Fritz gave an explanation for his absence, saying that he intended to return to the show after the scar from his back surgery healed. “I would like to return to the show,” Fritz remarked. Now that I’m fully recovered, I’m prepared to resume my role on the show.
Fritz claimed there had been no definitive decision made by the show regarding his return. He said, though, that a showrunner had given him a call and assured him that he would return to the screen.
Despite Fritz having worked on the show for ten years, TMZ claims that the show has “no plans” to employ him as a host once more.
In addition to not returning to his show, Bankson’s ex-boyfriend Eric Longlett, an engineering administration manager, made his debut. She gushed about how fortunate she was to be with him in posts about him on social media.
“He took me to see Elton John’s Yellow Brick Road Farewell Tour,” she captioned a photo of herself and Longlett together at the concert. I’m a fortunate woman. Love you, sweetie. oxo
Fritz was hospitalized on July 4, 2022, following a stroke. After finding him on his house floor, his companion had phoned for assistance. The 911 call in which his friend stated, “He might be seizuring, I’m not sure,” was obtained by The US Sun.
Bill Fritz, Fritz’s father, told the reporters that his son was healing nicely and getting better every day.
His recuperation was not as complete as the physicians had hoped, though. After being discharged from the hospital, he was placed under guardianship and sent to a nursing home.
On August 18, 2022, his “longtime friend” reportedly filed an emergency appointment for temporary guardianship and conservatorship on his behalf, which was subsequently approved.
The bank was designated as his conservator to manage his finances, and his friend was named as his guardian.
In its capacity as his conservator, the bank would manage all of his care facility bills, including daily costs, health insurance, maintenance, and property tax payments. The bank would have to make sure he could get to events and doctor’s visits in a suitable manner.
In addition to being “in decision-making since the stroke,” his friend’s guardianship required that he submit a “initial care plan” for the patient.
In order to achieve this, his guardian would have to make decisions about his living situation, place of residence at the time, health, and medical requirements. They would also need to arrange for him to participate in activities, maintain communication with him and his loved ones, and pursue romantic relationships. It would also be expected of him to provide an annual report as his guardian.
His health was getting worse, according to his papers, and it was making it more difficult for him to make wise decisions for himself, “without which physical injury or illness may occur.”
Documents revealed that he was unable to “make, communicate, or carry out important decisions concerning his own financial affairs,” indicating that his condition was far worse than previously believed.
His guardian will have to make decisions on his behalf as he heals and is able to “receive treatment for his injuries.”
The court determined that Fritz needs a guardian in order to prevent additional harm to his health. The court decided that “appointing a guardian and conservator is necessary to avoid immediate harm to him.”
This story really breaks my heart. We send Frank Fritz our best wishes for wellness and recovery.
Tell your friends and relatives about this so they can pray for the well-being of their beloved TV show presenter and learn what happened to him.
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