The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
My MIL Was Stealing My Clothes for Months and Advertising It Online — On Thanksgiving, I Publicly Taught Her a Lesson
When her favorite clothes start vanishing, Stephanie dismisses it as forgetfulness — until she discovers her mother-in-law secretly selling them online, calling them “trashy.” Living together during renovations just got interesting, and the family will never forget this Thanksgiving dinner.
I thought I had a good relationship with Lucia, my mother-in-law, until she moved in with us while her home was being renovated.
A woman standing beside several suitcases | Source: Midjourney
It started with small things, minor disagreements about why I put rosemary in my pot roast, and the “proper” way to clean the hardwood floors.
I tried to be a good host, but Lucia did not make it easy. One day, I returned from my part-time job to discover she’d rearranged everything stored in the kitchen cupboards. She also insisted on hanging the laundry outside to dry, even though I asked her not to.
“The fresh air just makes it smell better,” she said.
Laundry hanging on a clothesline | Source: Pexels
“That’s what the scented fabric softener is for,” I replied, but she just wouldn’t listen.
“You’re both very headstrong and like to do things your way, it’s natural you’ll clash from time to time,” Michael said when I ranted to him over a date night dinner. “And besides, Mom will be going back to her place in another few weeks. It’s not that long.”
“It may as well be forever,” I sighed.
Then my clothes started disappearing.
A confused woman standing in front of a closet | Source: Midjourney
It started with a semi-sheer dress. I wanted to wear it to a work function but when I opened my closet, it was gone.
“Lucia, have you seen my dress?” I called as I headed to the basement to search the laundry. “The mauve one, with the ruffles?”
“The one that looks like a curtain?” Lucia popped her head out of the living room as I passed by. “No, Steph, I don’t think I have.”
A woman shrugging | Source: Midjourney
I never did find that dress and the missing clothes situation got worse. My skinny jeans vanished next, followed by my fuschia pink sundress and — this one really got me — my favorite silk blouse that Michael had bought me for our anniversary.
I was going half-crazy thinking I’d misplaced them. I unpacked my entire closet and reorganized it three times. Every time, I noticed something else that was missing like a favorite bra, my lace pantyhose, and a grey pencil skirt.
But the real kicker? I discovered the truth about what was happening to my clothes purely by accident.
Close up of a frowning woman’s face | Source: Midjourney
I couldn’t sleep one night and ended up scrolling through Reddit. There, I stumbled upon a post showing MY CLOTHES, with a caption that made my blood boil: “Cleaning out my DIL’s trashy wardrobe. Anyone want to buy some clothes that no respectable married woman should wear?”
I nearly choked on my chamomile tea. The username might as well have been “LuciaTheThief” because who else could it be?
The woman who’d been living in my house for three months, eating my food, and criticizing my cooking, was now apparently stealing my clothes.
A woman staring at her phone screen in shock | Source: Midjourney
“Oh my God,” I whispered to myself, scrolling through the comments.
Some people wanted to buy the clothes while others had posted nasty criticisms of my fashion sense. She’d replied to some with remarks like, “My poor son doesn’t know how to tell her these clothes are inappropriate” and “She dresses like she’s still in college.”
I clenched my fists so hard that one of my acrylic nails popped off. I was tempted to storm into the guest bedroom right then and demand my clothes back, but then I came up with a better plan.
A woman scowling at her phone | Source: Midjourney
Thanksgiving was right around the corner and this year, Michael and I were celebrating with members from both our families. Twelve people in total, including Michael’s older brother and one of his aunts.
“Revenge is a dish best served with turkey and cranberry sauce,” I muttered as I took screenshots of Lucia’s Reddit post.
I set my phone aside and fell asleep with a smile on my face.
A cell phone on a nightstand | Source: Pexels
On Thanksgiving, I graciously told Lucia to go ahead and prepare the meal according to her family recipes. It kept her busy while I hurriedly completed the final steps of my plan to teach her a lesson.
Afterward, I set the table according to Lucia’s specifications. It looked perfect by the time everyone arrived. Michael squeezed my hand under the table as everyone sat down, probably thinking I was finally making an effort with his mother.
If he only knew.
A woman standing at a dining table | Source: Midjourney
When everyone had filled their plates, I stood up, wine glass in hand. “I’d like to make a toast,” I announced.
“To family,” I began, “and especially to Lucia, who’s been such a… presence in our home these past few months.” A few chuckles around the table. “She’s taught me so much about generosity and giving to others.”
Lucia beamed, probably thinking I’d finally learned something from her endless lessons about charity and community service. That’s when I reached under the table and pulled out the garbage bag I’d stashed there earlier.
A woman lifting a trash bag | Source: Midjourney
“In fact, she’s generously donated all of these clothes to the women’s shelter downtown,” I continued, “accidentally” letting the bag split open.
Out tumbled Lucia’s favorite cashmere sweater, her designer jeans, and — oops — was that her La Perla lingerie skittering across the hardwood floor?
Lucia took one look at the clothes, all items I’d carefully chosen because I knew she loved them, and spat her wine out like a fountain.
A shocked woman seated at a dining table | Source: Midjourney
The table went silent. Michael’s sister Jane stopped mid-chew. Then, surprisingly, Michael’s cousin Sarah started clapping.
“That’s so wonderful of you, Aunt Lucia!” Sarah exclaimed. “You’re always talking about giving back to the community. How generous of you to donate your designer clothes!”
Others joined in the applause, praising Lucia’s apparent selflessness. I watched as her face cycled through confusion, horror, and fury, knowing she couldn’t say a word without exposing her misdeeds.
A smug woman | Source: Midjourney
It was the perfect trap.
The rest of dinner was deliciously awkward, with Lucia pushing food around her plate and avoiding everyone’s eyes.
I’d never seen her so quiet during a family gathering. Usually, she’d be holding court, sharing stories about Michael’s childhood, or dropping not-so-subtle hints about grandchildren.
After dinner, Lucia cornered me in the kitchen.
An angry woman | Source: Midjourney
Her face was flushed, either from anger or the three glasses of wine she’d needed to get through dessert.
“How dare you humiliate me like that?” she hissed, hands shaking as she gripped the counter. “You went too far, Stephanie. Way too far.”
I continued loading the dishwasher, taking my time with each plate. “How dare I? That’s rich coming from someone who stole my clothes and tried to sell them online while calling me trashy.”
A woman loading a dishwasher | Source: Midjourney
“What? I… I don’t know what you’re talking about.”
I paused, took out my phone, and showed her the screenshot I’d taken of her Reddit post. The blood drained from her face and her jaw went slack.
“I… well, those clothes were inappropriate—”
“Those clothes were mine,” I cut her off. I scrolled to the next screenshot. “Every single comment you made, every attempt to sell my things — it’s all here.”
An angry woman | Source: Midjourney
“And let me make something crystal clear: my house, my clothes, my life,” I continued. “You don’t get to make those decisions for me anymore. Actions have consequences, Lucia. Remember that next time you think about overstepping.”
The next morning, I found all my missing clothes neatly folded outside my bedroom door. Every single item was there, from the semi-sheer dress to the silk blouse.
No note needed — the message was clear.
A stack of folded clothes on a hallway table | Source: Pexels
I gathered them up and took them to my closet, then spent an hour sorting through my older clothes.
When Lucia came down for breakfast, I was already at the door with my donation bag.
“Going to the shelter?” she asked quietly.
“Yes. With my own clothes… the ones I actually want to donate.”
A woman carrying a trash bag | Source: Midjourney
She nodded, then surprised me by saying, “I’m sorry, Stephanie. I was wrong.”
I paused at the door, bag in hand. “I know you were.”
“It’s just…” she sighed, wringing her hands. “Those clothes, some of them seemed so revealing, and I worried about what people would think. About you, about Michael, about our family. But I handled it all wrong. It won’t happen again.”
“No,” I agreed, “it won’t.”
A woman holding a trash bag | Source: Midjourney
As I drove to the shelter, I couldn’t help but smile. Sometimes it takes a little public humiliation to teach someone about boundaries. And if Lucia ever tried something like this again? Well, I still had those Reddit screenshots saved on my phone.
Just in case.
But for now, we had reached a tentative peace. The following weeks brought fewer criticisms, more respect for personal space, and — miracle of miracles — not a single comment about my wardrobe choices.
A woman relaxing on a sofa | Source: Midjourney
Sometimes, it takes a dramatic gesture to reset a relationship.
Here’s another story: After weeks of planning the perfect Christmas Eve, my husband left the kids and me at home to attend his staff-only office party instead. But when another wife’s call revealed the truth about couples being invited, I decided it was time for a surprise visit.
This work is inspired by real events and people, but it has been fictionalized for creative purposes. Names, characters, and details have been changed to protect privacy and enhance the narrative. Any resemblance to actual persons, living or dead, or actual events is purely coincidental and not intended by the author.
The author and publisher make no claims to the accuracy of events or the portrayal of characters and are not liable for any misinterpretation. This story is provided “as is,” and any opinions expressed are those of the characters and do not reflect the views of the author or publisher.
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