The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Julie Andrews makes rare public appearance at 87, and everyone’s saying the same thing
One of the most active actors in her generation is Julie Andrews. There is no denying her impact on the Hollywood industry.
The actress has hardly been spotted in public recently. But everyone is expressing the same sentiment in response to her most recent public appearance…
Julie Andrews’ parents were vaudeville artists, thus she was raised in a world full with entertainment. Early on, she demonstrated an interest in performing, and eventually went on to achieve great achievements and leave a lasting impression on the acting industry. For her portrayal of Mary Poppins, she received an Academy Award.
The actress said of the role and film, “It was a brand new thing in my life that I’d never done before. It was for Walt Disney, of course, and the songs in Mary Poppins had a kind of Vaudeville quality to them.”
“I think it’s what attracted me to the role, because all that kind of Supercalifragilisticexpialidocious and Jolly Holiday music was very much like the kind of things that you hear in English vaudeville,” the actress added.
Andrews assisted Disney in setting records with Mary Poppins. The movie received 13 Academy Award nominations and ended up becoming the highest-grossing movie of 1964.
Andrews said how the inspiration for the Mary Poppins attire came from her ex-husband Tony Walton. His suggestions led to the decision to use colorful patterns on the inside while portraying a more “uniform” appearance on the outside. She disclosed what Tony had said to her at that time., “Because I think that’s what gives her pleasure. Very formal on the outside and a little bit wicked on the inside.”
“It completely gave me a clue as to her character. Big, big help for me,” she later recalled, giving him his due credit. The actress went on to play her iconic role as Maria von Trapp in The Sound Of Music. Recently, she narrated Netflix’s Bridgerton series as Lady Whistledown.
However, the actress did not appear on camera; she merely provided the voice for the narration. She also eliminated any chance that it would occur.
“No, no, no,” she said when asked about the possibility of a role in front of the camera. “You know who Lady Whistledown really is, so I’m afraid it stays with me in the background. But I’m very happy to do that.
Because the actress just made a rare public appearance, fans who were eager to see her can now relax. At the Sag Harbor farmers’ market in The Hamptons on Long Island, New York, the 87-year-old veteran actress was spotted.
She was attractive as she waved to passersby and used her cane to stroll. Fans are not accustomed to seeing the actress walking with a cane. Before heading to her car, she was observed purchasing two boxes of Lu Petit Ecolier European dark chocolate biscuits and some flowers.
Julie Andrews, who is renowned for her traditional manner, did not let us down in this instance either. The actress wore fitting gray pants and a light gray long-sleeve top. She completed her outfit with a white scarf around her neck, a beige tote purse, white sneakers, and gold stud earrings.
A man placed an umbrella over her as she attempted to get into the SUV because it had started to rain. In the images posted online, she appeared to be rather gorgeous.
Everyone thought the actress looked stunning. A user of X (formerly known as Twitter) commented that the actress looked “lovely as ever.” Another person said she was “so beautiful.”
Julie Andrews is unquestionably still as endearing as ever. Her well-known smile, which has for decades warmed the hearts of millions, still has the same impact.
If you enjoyed this article, you may also enjoy Barbra Eden, who earlier this year made a rare public appearance at the age of 92.
What do you think about Julie Andrew’s public appearance?
Let us know in the comments. Share this with other fans of the actress so they can see how lovely she looks as well.
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