The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
6-Year-Old Boy Dies And Leaves Blue Stain On Carpet: Years Later, Mom Makes Heart-Wrenching Discovery
Every day, moms have a lot on their plates.
Managing multiple responsibilities throughout the day, like cleaning their children’s sticky hands and faces, folding laundry, ensuring they eat breakfast and lunch, and getting them ready for school, leaves parents with a lot on their plates and little time for relaxation.
No matter how hard they try, there will always be some sort of mishap—such as a toy you trip over, a glass of milk that gets knocked over, or a stain somewhere—waiting around the corner.
The luxury of taking a quick shower before going to bed or spending some alone time is something that many mothers cannot afford.
A mother who has seen it all, Heather Duckworth, recently wrote a piece in which she touched on some of the things we take for granted as parents.
A crucial component of that process is the mess that children make as they transform before our own eyes into the people we’ve always thought they’ll become.
It’s crucial to keep in mind that our kids will use the messes we cleaned up when they were adults as the greatest evidence to the upbringing we provided for them, so it’s worthwhile to make an effort to find happiness even in the middle of turmoil.
Unfortunately, not every woman gets to witness the chaos and disarray that kids bring about.
Not all parents are able to experience the happiness that children bring into their life, either.
Many new and expecting mothers connected with Heather’s widely shared post , “The Blue Stain.”
As Heather washed the grout her daughter had created with the slime, her heart began to race as she recalled the catastrophe she had to clean up all those years prior.
This mother would think, “My hands were full, but so was my heart,” after a demanding day of chasing after her two-year-old triplets and her four-year-old elder brother, picking up toys, and making sure no one got hurt in the mountains of laundry she was unable to finish that day.
Heather and her two sons danced to the radio as they cleaned up the playroom before calling it a night.
It was the last time they would laugh so hard for a while, no one could have anticipated.
She was about to go to sleep herself when she heard one of the boys say, “Uh, Oh,” and she noticed the enormous blue stain that would follow her about for the rest of her life.
One of the triplets’ pens exploded in his hand, splattering ink all over the place. Blue pajamas, hands, and face gave the appearance that the little child was a smurf.
Heather became enraged and felt like a lousy mother as she watched.
Although she hadn’t been upset with her son, she did blame herself since she’d placed the pen in a place where kids could readily get to it. She gave in to her emotions.
“When I noticed blue splatters all over the floor and a large pool of ink seeping into our brand-new carpet, I panicked. My husband had been doing the dishes, so I hurriedly shouted for him to come help me. My spouse began cleaning those vivid blue stains off of our carpet as soon as I got my son and took him to the toilet to clean him up. I was immediately upset.
Heather would often get angry and frustrated when she spotted the stain on the brand-new carpet. Up until the day it was eventually removed, the stain represented all the amazing experiences she shared with her sons.
A month after the little child spilled blue paint on the carpet, he was given a cancer diagnosis. Two years later, he passed away, leaving the stain as a reminder of their time together.
It remained in place, but now it served as a continual reminder of my kid. It served as a continual reminder of my annoyance at something so little and insignificant in the grand scheme of things.
The blue stain served as a continual reminder that although life is messy, it is still worthwhile. a persistent prompt to stop worrying about the little things. a continual reminder that people matter more than “things.” a continuous reminder that mishaps do occur. a continual reminder to hold fast to what is important and let go of the trivial things.
She attempted to hide the bright blue stain with the furniture, but each time she tidied the space, it was there, glaring back at her, a constant reminder of her loss and the grief she was still experiencing.
The purpose of Heather’s narrative is to serve as a reminder of how frequently we forget to see the small things in life that bring us purpose and take life for granted. She feels compelled to tell all the mothers out there that the toys scattered around and the filthy clothes are what actually provide their homes a feeling of security and comfort for their family.
As Heather puts it, those messes caused by the people we care about the most are what give our lives meaning because the day will come when we will truly miss those times.”If it meant I could spend one more day with my son, I would gladly have a million blue ink stains on my carpet.”
She gives mothers this advice: try not to become so engrossed in the world that you lose out on spending valuable time with your children. Prioritize what really important in life since it’s too short to waste time cleaning stains!
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