The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
How Often You Should Really Be Showering…
The Great Shower Debate: Morning vs. Night vs. No Shower
Showering is a daily ritual for many, but opinions vary on the best time to do it and whether it should even be done daily. Let’s explore the different perspectives on showering, its benefits, and factors to consider for optimal skin health.
Morning Showers: A Fresh Start
For some, a morning shower is an essential part of their routine. It serves as a refreshing wake-up call, helping to shake off sleepiness and prepare for the day ahead. The warm water can stimulate circulation and promote alertness, while the act of showering can be a time for mindfulness and setting intentions for the day.
Benefits:
- Boosts energy levels and alertness.
- Helps with mental clarity and focus.
- Can serve as a form of self-care.
Night Showers: Unwinding After a Long Day
On the other hand, many people prefer to shower at night. A warm shower can help relax muscles, soothe tension, and signal to the body that it’s time to wind down. This practice can improve sleep quality by lowering body temperature after stepping out of the shower, which can help cue the body for sleep.
Benefits:
- Promotes relaxation and helps reduce stress.
- Cleanses the skin of dirt and sweat accumulated throughout the day.
- Can improve sleep hygiene.
Skipping Daily Showers: A Skin Health Perspective
Some individuals choose to skip daily showers, believing that frequent washing can lead to dryness and irritation of the skin. This perspective is particularly common among those with sensitive skin or specific skin conditions, like eczema.
Considerations:
- Skin health varies from person to person; some may benefit from less frequent washing.
- Environmental factors (humidity, climate) and personal activity levels play a role in how often one should shower.
- For those who prefer to skip a daily shower, alternative hygiene practices, like washing specific areas or using cleansing wipes, can maintain cleanliness.
Finding Your Balance
Ultimately, the best shower routine varies by individual and should take into account factors like skin type, lifestyle, and personal preferences. It’s essential to listen to your body and adjust your routine to suit your needs.
Whether you prefer morning showers to kickstart your day, night showers to unwind, or occasional skipping to maintain skin health, understanding the benefits and considerations can help you make informed choices. After all, the goal is to feel clean, refreshed, and comfortable in your own skin—no matter when you choose to shower!
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