The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Taylor Swift’s NYC Date Night with Travis Kelce: Fans Outraged Over Shocking Outfit!
Some Swifties are trying to figure out what the details on Taylor Swift’s bag mean. She carried it during a date night in a much-discussed outfit.
On October 12, Taylor Swift and Travis Kelce were seen enjoying a date night at Torrisi restaurant in New York City. They both looked stylish, but Swift’s all-gold outfit attracted a lot of attention.
While Kelce wore a blue T-shirt from Marni and khaki cargo pants, Swift chose an “Ivy Corset” and “Ivy Skirt” from Annie’s Collection by Annie’s Ibiza, which cost around $795 (£590) for both items.
The singer paired her outfit with $1,140 black platform mules from Versace. She also wore gold jewelry, let her hair down, and carried a $1,423 black and gold shoulder bag from designer Roberto Cavalli.
When photos of Swift and Kelce walking hand-in-hand to the restaurant surfaced, many people took to social media to comment on her look.
“Omg someone get her a stylist because this isn’t it,” one person said. Another echoed, “She could use a stylist. Especially with her money.”
Someone else wondered, “I wonder if she owns any nice clothes? Even jeans and a t-shirt?” Another commenter pleaded, “Just get rid of the bangs already, Taylor.”
More critical remarks followed, with users writing comments like, “Her dress sense is horrible… no style at all,” and “Why is she wearing a costume?”
“It’s giving curtain,” one person joked. Meanwhile, a fan on the fence expressed, “I love Taylor but this new style is…” Another person commented, “These outfits are a disaster.”
However, some comments were positive. “Taylor Swift is SO beautiful,” gushed one admirer. Another said, “Taylor and Travis both look so gorgeous. I love them together.”
A fan added, “They look great! Stylish couple.” Another praised, “Love the snake purse,” referring to the gold monogram on Swift’s Cavalli bag.
The bag featured the letter “R” in the center of two intertwined “C’s” made from gold snakes, leading many Swifties to speculate about its meaning.
Fans wondered if the emblem on the bag hinted at Swift possibly announcing “Reputation (Taylor’s Version)” soon.
“Taylor Swift rocking a bag with the letter ‘R’ and snakes? Could it be ‘Reputation’ era vibes coming back?” one fan wrote. Another added, “Taylor never does anything by accident. Is this a new era of Renaissance or just a nod to the fans?”
Fans are excited because Swift often leaves “easter eggs” to hint at her upcoming plans. They noted that she has already released “Taylor’s Version” of her other albums, leaving only “Reputation” and “1989” expected to drop.
Before the comments about her designer bag, fans thought Swift might announce “Reputation (Taylor’s Version)” during her Eras Tour shows in Australia or Japan in February 2024. They thought this because of an easter egg in her music video for “Bejeweled.”
However, instead, she released her latest album, “The Tortured Poets Department.” On August 20, fans expected an announcement on stage, like she did with “1989 (Taylor’s Version)” and “Speak Now (Taylor’s Version).”
That moment passed, and Swift released the music video for “I Can Do It with a Broken Heart.” Still, fans have continued to speculate about “Reputation.”
Currently, some Swifties think the album might be announced on October 18, the day she starts the final leg of her tour.
As fans await the album announcement, Swift is enjoying her time with her footballer boyfriend.
Before their recent outing in New York City, they had dinner on October 11 with Blake Lively and Ryan Reynolds.
A few days earlier, on October 7, Swift showed her support for Travis Kelce at Arrowhead Stadium while his team, the Kansas City Chiefs, played against the New Orleans Saints.
According to a source, Kelce and Swift’s relationship is “beautiful,” and they manage to balance their busy lives. “It’s all about work-life balance, and everyone is dealing with different things. They just acknowledge how hard it is to manage relationships and everything else,” the source said.
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